Article Health And Fitness | How To Prevent Prostate Problems and Diseases?How To Prevent Prostate Problems and Diseases?

By: Cindy Heller

The prostate gland is an essential part of a male’s reproductive system. It secretes fluids that aid in the transportation and activation of sperm. The pro…

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Men who are overweight or obese have lower concentrations of prostate-specific antigen (PSA) in their blood than their normal-weight counterparts, according to a new study led by Duke University Medical Center researchers.The finding echoes earlier results on PSA concentrations found in obese and ov…

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UroToday.com - AT1 receptor blockers (ARBs) possessing our experimental demonstrations may offer clinical efficacy in patients with hormone refractory prostate cancer (HRPC).In practice, we conducted a pilot clinical study to examine whether an ARB (candesartan) was able to clinically elicit an anti…

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UroToday.com - Dr. Nelson discussed that androgen-independent CaP progression is not really independent of androgens. Using microarray based expression profiling in LNCaP cells, gene expression following androgen deprivation therapy was performed. They sought to identify the regulatory cascade gover…

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UroToday.com - Dr. Oh reviewed the past and present of secondary hormonal therapies. He showed patient cases of sequential secondary therapies with outcomes supporting the heterogeneity of CaP. Some patients metastasize thereupon develop castration resistant prostate cancer (CRPC) while others have …

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UroToday.com - John Isaacs, Johns Hopkins discussed stem cell biology. Cancer is caused by a series of genetic changes (both germ line and somatic). Genetic instability can occur even in cancer cells, influencing their behavior. He cited the Gleason scoring system as an example of phenotypic heterog…

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UroToday.com - Dr. Danila, spoke about abiraterone acetate (AA), an oral and irreversible inhibitor of CYP17 that decreases testosterone and DHT levels to undetectable. The study presented sought to determine the proportion of patients achieving a PSA decline of >50% and to assess toxicity. It wa…

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UroToday.com - June Chan from UCSF presented on Nutritional Epidemiology of Prostate Cancer. In a population migration study, low-risk CaP populations moving to a high-risk area shifted to a higher risk profile. Chinese men in China had a CaP risk of 3/100,000, but after moving to the US that increa…

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UroToday.com - Dr. Mostaghel reviewed the potential sources of tissue androgens from the androgen metabolic pathway. that includes the uptake and conversion of circulating adrenal androgens, and the de novo androgen biosynthesis of androgens from cholesterol, progesterone or earlier precursors.Tumor…

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UroToday.com - that study sought to compare survival in a prospective randomized trial of radiotherapy (XRT) alone vs. XRT with 6 months of ADT. 206 men were accrued and randomized. They all had at least one unfavorable-risk factor. 70 Gy of XRT was given. The lymph nodes were not treated. ADT was 2…

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Poniard Pharmaceuticals, Inc. (Nasdaq: PARD), a biopharmaceutical company focused on oncology, announced that it is presenting safety and efficacy notes in prostate cancer patients from its Phase 1 study of picoplatin, the Company’s lead product candidate, at the 2008 Genitourinary (GU) Cancers Symp…

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